For the first 13 years the medicine and treatment plans worked well. My health still alternating between hypomania (well) and severe clinical depression (very unwell), these being the characteristics of Bipolar. Thank God I was able to recover from the clinical depression within 2 weeks to a month after my Doctor increased the dosage of my anti-depressant whenever I have relapses. Once I was well, the dosages are lowered back to my regular dosage.
But over the last 2 year, 2 of the 4 medicines I have been taking, didn't work any more despite increased in dosages. It seems that my body has got used to them after taking them for 13 years. So I began to feel unwell. I realized that due to aging and menopause, my body is also undergoing some changes which also affect my whole body.
My Doctor is making some changes in my medicine as well as finding new treatment plans. For 2 years now, she has been trying me out with combinations of some new medicines and trying to find optimal dosages for my health to get better and stabilise.
So far, she has not found the right combinations of new medicines and the optimal dosages yet. It generally takes around 6 months for old medicines to leave my body system. So it also takes that long for the new replacement medicine to work.